NMN Study #1
Medicine is constantly renewing itself. More and more studies and research are being carried out that lead to the advancement of techniques, medications, and procedures with the aim of improving the quality of life and even human longevity.
Among these studies are those on the effects of NMN on the human body.
A natural substance previously shown to counteract the effects of aging and improve metabolic health in mice could have relevant effects in humans, according to research conducted by a team from the Washington University School of Medicine in St. Louis (United States).
The research, published in the journal Science, is the first randomized clinical trial to analyze the metabolic effects of the administration of the compound called nicotinamide mononucleotide (NMN) in humans.
Specifically, a small trial was conducted with postmenopausal women with prediabetes that showed how this compound "improved the ability of insulin to increase glucose uptake in skeletal muscle," notes the statement issued by the University.
This compound previously studied for aging also improved "the expression of genes that are involved in muscle structure and remodeling". However, NMN treatment did not reduce "blood glucose or blood pressure, nor did it decrease circulating markers of inflammation as observed in mice," they add.
To carry out the trial, the team of researchers administered 250 mg of this compound orally to 13 women who received it every day for a period of 10 weeks. On the other hand, a total of 12 women participants received a placebo during this same period to test the differences.
"Even though our study does show that NMN has a beneficial effect on skeletal muscle, it is still too fast to make clinical recommendations with just the results of our study as a base” stresses lead investigator Samuel Klein, the William H. Danforth Professor of Medicine and Nutritional Science and director of the Center for Human Nutrition.
Although there were some good results, researchers agreed that there will have to be more studies in order to determine the beneficial effects that NMN might have in the management and/or prevention of diabetes. Evaluations to further investigate NMN effects in men and women are being carried out by Imai and Klein.
Shin-ichiro Imai, professor of developmental biology and medicine and one of the principal investigators said that "This is a step toward the development of an anti-aging drug, although more research is needed to fully understand the cellular mechanisms responsible for the effects observed in skeletal muscle in people”.
Washington University School of Medicine. "Anti-aging compound improves muscle glucose metabolism in people: Further studies underway to determine the extent of clinical benefits." ScienceDaily. www.sciencedaily.com/releases/2021/04/210422150349.htm