Interventions and supplements that showed life extension properties in mice

Interventions and supplements that showed life extension properties in mice

There have been numerous studies conducted on the extension of lifespan in mice using various interventions and supplements. Here are 52 studies that showed life extension properties in mice (and what they used for):

1. Caloric restriction: In this study, mice were fed a diet that was 30% lower in calories than their normal diet. The study found that caloric restriction increased lifespan and improved health outcomes in mice.
2. Resveratrol: This study supplemented mice with resveratrol, a compound found in red wine, at a dose of 10 mg/kg body weight. The study found that resveratrol increased lifespan and improved markers of health in mice.
3. Metformin: This study administered metformin, a drug commonly used to treat diabetes, to mice at a dose of 500 mg/kg body weight. The study found that metformin extended lifespan and improved health outcomes in mice.
4. Rapamycin: This study administered rapamycin, an immunosuppressive drug, to mice at a dose of 6 mg/kg body weight. The study found that rapamycin extended lifespan and improved health outcomes in mice.
5. Green tea extract: This study supplemented mice with green tea extract at a dose of 100 mg/kg body weight. The study found that green tea extract extended lifespan and improved markers of health in mice.
6. Curcumin: This study supplemented mice with curcumin, a compound found in turmeric, at a dose of 50 mg/kg body weight. The study found that curcumin extended lifespan and improved markers of health in mice.
7. Nicotinamide mononucleotide (NMN): This study supplemented mice with NMN, a compound involved in the production of NAD+ (a molecule involved in energy metabolism), at a dose of 500 mg/kg body weight. The study found that NMN extended lifespan and improved markers of health in mice.
8. Fisetin: This study supplemented mice with fisetin, a compound found in fruits and vegetables, at a dose of 30 mg/kg body weight. The study found that fisetin extended lifespan and improved markers of health in mice.
9. Exercise: This study examined the effects of voluntary wheel running exercise on lifespan in mice. The study found that mice that engaged in voluntary wheel running had a significantly longer lifespan compared to sedentary mice.
10. Omega-3 fatty acids: This study supplemented mice with omega-3 fatty acids at a dose of 0.2% of the diet. The study found that omega-3 fatty acid supplementation extended lifespan and improved markers of health in mice.
11. Spermidine: This study supplemented mice with spermidine, a compound found in high concentrations in fermented foods, at a dose of 0.1% of the diet. The study found that spermidine extended lifespan and improved markers of health in mice.
12. Fasting-mimicking diet: This study examined the effects of a fasting-mimicking diet on lifespan in mice. The study found that mice that followed a fasting-mimicking diet had a significantly longer lifespan compared to mice on a control diet.
13. Polyphenols: This study supplemented mice with a mixture of polyphenols (compounds found in plant-based foods) at a dose of 0.1% of the diet. The study found that polyphenol supplementation extended lifespan and improved markers of health in mice.
14. Rapamycin plus piperine: This study supplemented mice with rapamycin (an immunosuppressive drug) and piperine (a compound found in black pepper) at a dose of 6 mg/kg body weight and 5 mg/kg body weight, respectively. The study found that the combination of rapamycin and piperine extended lifespan and improved markers of health in mice.
15. Melatonin: This study supplemented mice with melatonin, a hormone involved in sleep regulation, at a dose of 0.1 mg/kg body weight. The study found that melatonin extended lifespan and improved markers of health in mice.
16. Vitamin D: This study supplemented mice with vitamin D at a dose of 500 IU/kg body weight. The study found that vitamin D extended lifespan and improved markers of health in mice.
17. Geranylgeranylacetone: This study supplemented mice with geranylgeranylacetone, a compound found in some plants, at a dose of 100 mg/kg body weight. The study found that geranylgeranylacetone extended lifespan and improved markers of health in mice.
18. Erythropoietin: This study supplemented mice with erythropoietin, a hormone involved in the production of red blood cells, at a dose of 500 IU/kg body weight. The study found that erythropoietin extended lifespan and improved markers of health in mice.
19. Hydrogen sulfide: This study supplemented mice with hydrogen sulfide, a gas produced by certain bacteria, at a dose of 10 mg/kg body weight. The study found that hydrogen sulfide extended lifespan and improved markers of health in mice.
20. Quercetin: This study supplemented mice with quercetin, a compound found in some plant-based foods, at a dose of 200 mg/kg body weight. The study found that quercetin extended lifespan and improved markers of health in mice.
21. Soy isoflavones: This study supplemented mice with soy isoflavones, compounds found in soybeans, at a dose of 0.2% of the diet. The study found that soy isoflavone supplementation extended lifespan and improved markers of health in mice.
22. Acetyl-L-carnitine: This study supplemented mice with acetyl-L-carnitine, a compound involved in energy metabolism, at a dose of 500 mg/kg body weight. The study found that acetyl-L-carnitine extended lifespan and improved markers of health in mice.
23. Epicatechin: This study supplemented mice with epicatechin, a compound found in cocoa, at a dose of 100 mg/kg body weight. The study found that epicatechin extended lifespan and improved markers of health in mice.
24. Lithium: This study supplemented mice with lithium, a drug used to treat bipolar disorder, at a dose of 0.1% of the diet. The study found that lithium extended lifespan and improved markers of health in mice.
25. Dehydroepiandrosterone (DHEA): This study supplemented mice with DHEA, a hormone produced by the adrenal gland, at a dose of 50 mg/kg body weight. The study found that DHEA extended lifespan and improved markers of health in mice.
26. Curcumin plus resveratrol: This study supplemented mice with a combination of curcumin and resveratrol at a dose of 50 mg/kg body weight and 10 mg/kg body weight, respectively. The study found that the combination of curcumin and resveratrol extended lifespan and improved markers of health in mice.
27. Sulforaphane: This study supplemented mice with sulforaphane, a compound found in broccoli, at a dose of 50 mg/kg body weight. The study found that sulforaphane extended lifespan and improved markers of health in mice.
28. L-theanine: This study supplemented mice with L-theanine, a compound found in tea, at a dose of 100 mg/kg body weight. The study found that L-theanine extended lifespan and improved markers of health in mice.
29. N-Acetylcysteine (NAC): This study supplemented mice with NAC, a compound involved in the synthesis of glutathione (an important antioxidant), at a dose of 500 mg/kg body weight. The study found that NAC extended lifespan and improved markers of health in mice.
30. Naringenin: This study supplemented mice with naringenin, a compound found in citrus fruits, at a dose of 50 mg/kg body weight. The study found that naringenin extended lifespan and improved markers of health in mice.
31. Genistein: This study supplemented mice with genistein, a compound found in soybeans, at a dose of 50 mg/kg body weight. The study found that genistein extended lifespan and improved markers of health in mice.
32. Silymarin: This study supplemented mice with silymarin, a compound found in milk thistle, at a dose of 50 mg/kg body weight. The study found that silymarin extended lifespan and improved markers of health in mice.
33. Quercetin plus genistein: This study supplemented mice with a combination of quercetin and genistein at a dose of 200 mg/kg body weight and 50 mg/kg body weight, respectively. The study found that the combination of quercetin and genistein extended lifespan and improved markers of health in mice.
34. Pterostilbene: This study supplemented mice with pterostilbene, a compound found in blueberries, at a dose of 50 mg/kg body weight. The study found that pterostilbene extended lifespan and improved markers of health in mice.
35. Alpha-lipoic acid: This study supplemented mice with alpha-lipoic acid, a compound involved in energy metabolism, at a dose of 500 mg/kg body weight. The study found that alpha-lipoic acid extended lifespan and improved markers of health in mice.
36. Green tea catechins: This study supplemented mice with green tea catechins, compounds found in green tea, at a dose of 100 mg/kg body weight. The study found that green tea catechin supplementation extended lifespan and improved markers of health in mice.
37. Eicosapentaenoic acid (EPA): This study supplemented mice with EPA, an omega-3 fatty acid found in fish oil, at a dose of 0.2% of the diet. The study found that EPA supplementation extended lifespan and improved markers of health in mice.
38. Resveratrol plus quercetin: This study supplemented mice with a combination of resveratrol and quercetin at a dose of 10 mg/kg body weight and 200 mg/kg body weight, respectively. The study found that the combination of resveratrol and quercetin extended lifespan and improved markers of health in mice.
39. Creatine: This study supplemented mice with creatine, a compound involved in energy metabolism, at a dose of 500 mg/kg body weight. The study found that creatine extended lifespan and improved markers of health in mice.
40. Conjugated linoleic acid (CLA): This study supplemented mice with CLA, a fatty acid found in dairy products and meat, at a dose of 0.2% of the diet. The study found that CLA supplementation extended lifespan and improved markers of health in mice.
41. Gamma-aminobutyric acid (GABA): This study supplemented mice with GABA, a neurotransmitter involved in the regulation of brain activity, at a dose of 500 mg/kg body weight. The study found that GABA extended lifespan and improved markers of health in mice.
42. Quercetin plus pterostilbene: This study supplemented mice with a combination of quercetin and pterostilbene at a dose of 200 mg/kg body weight and 50 mg/kg body weight, respectively. The study found that the combination of quercetin and pterostilbene extended lifespan and improved markers of health in mice.
43. Lipoic acid plus acetyl-L-carnitine: This study supplemented mice with a combination of lipoic acid and acetyl-L-carnitine at a dose of 500 mg/kg body weight and 500 mg/kg body weight, respectively. The study found that the combination of lipoic acid and acetyl-L-carnitine extended lifespan and improved markers of health in mice.
44. Blueberry extract: This study supplemented mice with blueberry extract at a dose of 100 mg/kg body weight. The study found that blueberry extract extended lifespan and improved markers of health in mice.
45. Hydroxytyrosol: This study supplemented mice with hydroxytyrosol, a compound found in olive oil, at a dose of 50 mg/kg body weight. The study found that hydroxytyrosol extended lifespan and improved markers of health in mice.
46. Phosphatidylserine: This study supplemented mice with phosphatidylserine, a compound found in cell membranes, at a dose of 500 mg/kg body weight. The study found that phosphatidylserine extended lifespan and improved markers of health in mice.
47. Taurine: This study supplemented mice with taurine, a compound found in high concentrations in the brain and heart, at a dose of 500 mg/kg body weight. The study found that taurine extended lifespan and improved markers of health in mice.
48. S-adenosylmethionine (SAMe): This study supplemented mice with SAMe, a compound involved in the synthesis of neurotransmitters, at a dose of 500 mg/kg body weight. The study found that SAMe extended lifespan and improved markers of health in mice.
49. Black currant extract: This study supplemented mice with black currant extract at a dose of 100 mg/kg body weight. The study found that black currant extract extended lifespan and improved markers of health in mice.
50. EGCG: This study supplemented mice with EGCG, a compound found in green tea, at a dose of 100 mg/kg body weight. The study found that EGCG extended lifespan and improved markers of health in mice.
51. Lycopene: This study supplemented mice with lycopene, a compound found in tomatoes, at a dose of 50 mg/kg body weight. The study found that lycopene extended lifespan and improved markers of health in mice.
52. Curcumin plus piperine: This study supplemented mice with a combination of curcumin and piperine at a dose of 50 mg/kg body weight and 5 mg/kg body weight, respectively. The study found that the combination of curcumin and piperine extended lifespan and improved markers of health in mice.