Hallmarks of Aging and corresponding potential Peptides

Hallmarks of Aging and corresponding potential Peptides

Here are the hallmarks of aging and corresponding peptides that may have potential benefits:

1. Genomic instability:

• Klotho
• Thymosin Beta-4 (TB-4)
• Humanin
• Ghrelin
• Exenatide

2. Telomere attrition:

• Epithalon (Epitalon)

3. Epigenetic alterations:

• No specific peptides are directly associated with epigenetic alterations, but some peptides with general anti-aging effects, such as Klotho and Humanin, may indirectly influence epigenetic regulation.

4. Loss of proteostasis:

• No specific peptides have been identified for this hallmark, although more general anti-aging peptides like Klotho and Humanin may have indirect effects on proteostasis.

5. Deregulated nutrient sensing:

• Ghrelin
• Exenatide

6. Mitochondrial dysfunction:
   • Humanin
   • SS-31 (also known as Bendavia or MTP-131)
   • MOTS-c

7. Cellular senescence:

• FOXO4-DRI (a cell-penetrating peptide that selectively targets senescent cells)
• Thymosin Beta-4 (TB-4)

8. Stem cell exhaustion:

• • • • Thymosin Beta-4 (TB-4)
      • Klotho

9. Altered intercellular communication:

No specific peptides have been identified for this hallmark, although more general anti-aging peptides like Klotho and Humanin may have indirect effects on intercellular communication.

Please note that the evidence supporting the use of these peptides for addressing specific hallmarks of aging is still limited and mostly based on in vitro and animal studies. The optimal dosages, long-term safety, and efficacy of these peptides in humans remain to be established. Always consult with a healthcare professional before starting any new regimen or treatment plan.