Combination of several anti-aging methods
The world of science sometimes goes hand in hand with intellectual property. Scientific research studies, clinical trials, and so on, tend to be as secretive as the security of the US Pentagon: nobody knows about it until it's been done and finished. Afterward, everybody starts to make their own trials, in the search for better outcomes and results.
And perhaps this intellectual property and subsequent scientifical development control may be the reason why there are so few studies on the combination of anti-aging techniques. The existing studies are either already based on something known, or are on techniques that have little, significant effect on long-term longevity for us humans, and ironically produce significant gains in species with short lifespans.
At this very moment, researchers seem to have no knowledge of how the many different slow-aging approaches can interact with one another. In science, the question “what if…?” has been the propeller of many discoveries, inventions, and innovations. Such seems to be the case with this project in which the question is “what if different marginal approaches were combined in order to get a more impressive outcome?”.
Imagine combining different methods of plastic surgery such as liposuction, mammoplasty, bichectomy, and so on to create a fairly comprehensive and complex rejuvenation result... but inside your body, with cells, enzymes, and all that's involved. Amazing, isn't it?
This study aimed to investigate if the combination of several anti-aging actions can cause a cumulative effect on the extension of lifespan. The drugs used were mTOR signaling inhibitor rapamycin and two compounds from plants, carotenoid fucoxanthin, and alkaloid berberine, known for their geroprotective properties.
The effects of dietary restriction along with the co-administration of the aforementioned drugs with constant low temperatures and darkness on D-melanogaster flies were studied, and the results have been good! using a combination of geroprotective interventions the lifespan of flies was doubled, which is a lot more than using each intervention separately.
This is the first report on the increase of a flies’ lifespan to more than 200 days. The result most likely comes from the synergy of interventions that caused a reorganization of the global metabolic network and, ultimately, the modulation of several molecular signaling pathways.